11/25/2023 0 Comments Clindamycin side effects on skin![]() ![]() After oral administration of clindamycin hydrochloride, elimination half-life is increased to approximately 4.0 hours (range 3.4-5.1h) in the elderly compared to 3.2 hours (range 2.1-4.2h) in younger adults. Pharmacokinetic studies in elderly volunteers (61-79 years) and younger adults (18-39 years) indicate that age alone does not alter clindamycin pharmacokinetics (clearance, elimination half-life, volume of distribution, and area under the serum concentration time curve) after IV administration of clindamycin phosphate. No significant levels of clindamycin are attained in the cerebrospinal fluid, even in the presence of inflamed meninges. ![]() Doses of up to 2 grams of clindamycin per day for 14 days have been well tolerated by healthy volunteers, except that the incidence of gastrointestinal side effects is greater with the higher doses. Approximately 10% of the bioactivity is excreted in the urine and 3.6% in the feces The remainder is excreted as bio-inactive metabolites. The average biological half-life is 2.4 hours. Serum levels exceed the MIC (Minimum inhibitory concentration) for most indicated organisms for at least six hours following administration of the usually recommended doses.Ĭlindamycin is widely distributed in body fluids and tissues (including bones). Concentrations of clindamycin in the serum increased linearly with increased dose. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum. Serum half-life of clindamycin is increased slightly in patients with markedly reduced renal function. ![]() Serum level studies following multiple doses of clindamycin hydrochloride for up to 14 days show no evidence of accumulation or altered metabolism of drug. Absorption of an oral dose is virtually complete (90%), and the concomitant administration of food does not appreciably modify the serum concentrations serum levels have been uniform and predictable from person to person and dose to dose. An average peak serum level of 2.50 mcg/ml was reached in 45 minutes serum levels averaged 1.51 mcg/ml at 3 hours and 0.70 mcg/ml at 6 hours. Pharmacology: Pharmacokinetics: Serum level studies with 150 mg oral dose of clindamycin hydrochloride in 24 normal adult volunteers showed that clindamycin was rapidly absorbed after oral administration. ![]()
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